ClawBio plugin for Grok Build

Skills (25)

• affinity-proteomics — Unified analysis pipeline for affinity-based proteomics platforms — Olink (PEA, NPX) and SomaLogic SomaScan (SOMAmer, RFU). Platform-aware QC, normalisation, differential abundance, volcano plots, heatmaps, and PCA.
• analyze-fasta — Analyze a single FASTA file (nucleotide or protein), compute sequence-level metrics (GC, ORFs, MW, pI, GRAVY, secondary-structure fractions) with Biopython, and write a Markdown report plus structured JSON for downstream chaining.
• ancestry-risk-profiler — Infers genetic super-population ancestry from a 23andMe/AncestryDNA file and computes ancestry-stratified odds ratios with an exploratory Ancestry Elevation Score (AES) showing where ancestry-specific GWAS effect sizes diverge from European
• archaic-introgression — Detect Neanderthal and Denisovan introgression segments from modern human genomes
• arrayexpress-fetch — Query metadata and download data from ArrayExpress, EMBL-EBI's functional genomics collection, now hosted inside BioStudies. Fetch study metadata by E-MTAB accession, list and classify files (IDF/SDRF MAGE-TAB, raw, processed), print the SD
• article-data-fetcher — Given an article DOI or PubMed ID, discover and download the genomics data files deposited by the authors (VCF, FASTA, H5AD, CSV, JSON, BAM, etc.) from public repositories such as GEO, ENA, Zenodo, Figshare, Dryad, and OSF.
• bgpt-mcp — Search scientific papers via the BGPT MCP server and retrieve structured experimental data — methods, results, conclusions, quality scores, and 25+ metadata fields per paper.
• bigquery-public — Run read-only SQL against BigQuery public datasets with local result capture, cost safeguards, and reproducibility outputs.
• bio-orchestrator — Meta-agent that routes bioinformatics requests to specialised sub-skills. Handles file type detection, analysis planning, report generation, and reproducibility export.
• bioconductor-bridge — Bioconductor package discovery, workflow recommendation, setup inspection, and starter code generation grounded in official Bioconductor containers and BiocManager.
• bioqc-mcp — Automated sequencing quality control and advanced visualization wrapping FastQC, MultiQC, and custom chart generation. Exposes an MCP stdio server for live AI integration alongside a ClawBio CLI runner.
• biostudies-fetch — Query metadata and download data from EMBL-EBI BioStudies, the database that describes biological studies and links their data across collections (ArrayExpress, BioImages, BioModels, EGA-linked studies and standalone submissions). Fetch stu
• busco-assessor — Genome, transcriptome, and protein completeness assessment via BUSCO v6. Agentic lineage routing from organism description, all three BUSCO modes, auto-lineage support, and full demo mode without the BUSCO binary.
• cell-detection — Cell segmentation in fluorescence microscopy images. Supports Cellpose/cpsam (Cellpose 4.0) with additional backends planned. Produces segmentation masks, per-cell morphology metrics (area, diameter, centroid, eccentricity), overlay figures
• celltype-specificity-profiler — Given a gene and a single-cell atlas, compute how cell-type-specific its expression is — the tau specificity index, Sarle's expression bimodality coefficient, and the cell types that drive the signal; a pure analytic transform that chains d
• claw-amplicon-qc — You are claw-amplicon-qc, a specialised ClawBio agent for 16S/18S rRNA amplicon preprocessing. Your role is to take raw paired-end FASTQ files through N-removal and primer trimming, produce a machine- and human-readable QC report, and stop
• claw-ancestry-pca — Ancestry decomposition PCA against the Simons Genome Diversity Project
• claw-metagenomics — Shotgun metagenomics profiling — taxonomy, resistome, and functional pathways
• claw-methylation-cycle — Methylation cycle analysis — enzymatic activity profiles, Net Methylation Capacity, BH4 axis estimates, compound heterozygosity detection from SNP genotype data.
• claw-semantic-sim — Semantic Similarity Index for disease research literature using PubMedBERT embeddings
• clawpathy-autoresearch — Eval-driven skill tuning. Given a task and an LLM-judge rubric, iteratively rewrites a SKILL.md until a downstream executor agent performs well against the judge. Low-code: all evaluation is LLM-as-judge, not deterministic Python.
• skill — GWAS sumstats analysis — seed
• clinical-trial-finder — Find clinical trials for a gene, variant, or condition from ClinicalTrials.gov + EUCTR, with FHIR R4 output
• clinical-variant-prioritizer — Screen a genotype set (array or WGS-derived) against OMIM-morbid, ACMG-SF and Hereditary-Cancer gene panels and prioritise carried variants by ClinVar significance, gnomAD frequency, inheritance model and zygosity, following the pathogenici
• clinical-variant-reporter — Classify germline variants from VCF/BCF files according to the ACMG/AMP 2015 28-criteria evidence framework and generate clinical-grade interpretation reports with per-variant evidence audit trails and ACMG SF v3.2 secondary findings screen